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Read More Bystolic is a good blood pressure-lowering medicine for people with heart conditions, but it is expensive. Our systems can respond differently then others do to medications Yes, for me Bystolic is much better. This is not a complete list of side effects and others may occur. Bystolic is the newest beta blocker available in the U. LIke other beta blockers, the most common adverse events with Bystolic are headache, fatigue and dizziness. You have to be on time for your doses. My dad was not able to tolerate Metoprolol but when the doctor switched him over to Bystolic, he did not experience any of those side effects. Com The possibility of placebo effect of course cannot be excluded. Bystolic is used to treat hypertension (high blood pressure).